dermatan sulfate การใช้

• This is due to an excess of dermatan sulfate, a glycosaminoglycan.
• ARSB targets two GAGs in particular : dermatan sulfate and chondroitin sulfate.
• It is a component of dermatan sulfate and heparan sulfate, which are glycosaminoglycans.
• It consists of a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate.
• It is involved in the degeneration of glycosaminoglycans such as dermatan sulfate and heparan sulfate.
• Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
• The dermatan sulfate side chains of decorin aggregate in solution, and this behavior can assist with the assembly of the collagen fibrils.
• The degeneration occurs in conjunction with an accumulation of dermatan sulfate, a glycosaminoglycan, within the connective tissue matrix of the valve.
• Chondroitin sulfate and dermatan sulfate, which comprise CSGAGs, are differentiated from each other by the presence of GlcA and IdoA epimers respectively.
• Similar to the production of HSGAGs, C-5 uronyl epimerase converts d-GlcA to l-IdoA to synthesize dermatan sulfate.
• "Chondroitin sulfate B " is an old name for dermatan sulfate, and it is no longer classified as a form of chondroitin sulfate.
• Dermatan sulfate and heparan sulfate were the only GAGs containing IdoA, and they were the only ones that inhibited RSV infection in cell culture.
• The pathways for HS / heparin or chondroitin sulfate ( CS ) and dermatan sulfate ( DS ) biosynthesis diverge after the formation of this common linkage structure.
• The major GAG components of the tendon are dermatan sulfate and chondroitin sulfate, which associate with collagen and are involved in the fibril assembly process during tendon development.
• This natural primer acts as a template for the assembly of heparin sulfate, heparin, chondroitin sulfate, and dermatan sulfate side chains, depending on the tissue.
• Within the normal cornea, dermatan sulfate is fully hydrated whereas keratan sulfate is only partially hydrated suggesting that keratan sulfate may behave as a dynamically controlled buffer for hydration.
• Chondroitin sulfate shows slightly less biological activity than dermatan sulfate, and is composed of O-sulfonated N-Acetyl-D-galatosamine and D-glucuronic acid.
• Chondroitin sulfate chains are unbranched polysaccharides of variable length containing two alternating monosaccharides : L-iduronic acid ( IdoA ); the resulting disaccharide is then referred to as dermatan sulfate.
• Decorin is a proteoglycan that is on average 90-140 leucine repeats with a glycosaminoglycan ( GAG ) chain consisting of either chondroitin sulfate ( CS ) or dermatan sulfate ( DS ).
• Dermatan sulfate is thought to be responsible for forming associations between fibrils, while chondroitin sulfate is thought to be more involved with occupying volume between the fibrils to keep them separated and help withstand deformation.